Sasuke would be furious. He already has a strong sense of justice and loyalty to Naruto. He'd likely immediately start looking for Naruto, using his Sharingan to track any possible leads. He might even go against the village rules if he thought the village was involved in Naruto's kidnapping.
Sakura might be really surprised at first. She could offer to help Naruto with his girl disguise, teaching him things like how to do his hair or choose the right clothes. She might also find it a bit funny but would be supportive in the end, seeing it as part of a mission. Sasuke, on the other hand, might be a bit more aloof. He would probably just raise an eyebrow at Naruto's new look but wouldn't make a big fuss about it as long as it was for a good reason.
His friends would be shocked at first. Sasuke might feel a sense of responsibility to find Naruto and bring him back. Sakura would probably feel guilty, especially if she was somehow involved in the situation that led to Naruto being cheated on.