During the Second Great Ninja War, one of the highlights was Tsunade cracking the poison created by Chiyo. This was a critical moment in the history of the war, though Orochimaru had long since pushed the memory to the back of his mind.
But after being reincarnated in this new world and discovering that he had a system, Orochimaru made sure to record every scrap of memory he could recall in the system's archives. With his current enhanced mental power, those long-forgotten details were sharper than ever.
Still, despite his recollections, Orochimaru couldn't pinpoint exactly when the infamous duel between Tsunade and Chiyo began, or how long it lasted. All he knew was that it was bound to happen sooner or later, and the thought intrigued him.
With curiosity piqued, Orochimaru slowly rose from his seat and left the command tent.
When he arrived at the medical tent, he saw about five or six Konoha ninjas laid out on the ground, their skin marred by black wounds. All of them were unconscious, breathing weakly.
Tsunade was bent over one of the injured, using a silver needle to draw out the poison that had seeped into their bodies.
Orochimaru inquired and learned that more than a dozen Konoha ninjas had already died from the toxin. The ones who had survived had managed to escape and were rescued by reinforcements.
This is war constant attacks and counterattacks, each side inflicting as much harm as possible. This was the reality of the battlefield.
At the treatment station, after extracting the toxin, Tsunade immediately moved to the area where the medical team was stationed and began preparing the antidote. She was fully concentrated, devoid of her usual impulsiveness or short temper. When it came to her craft, Tsunade's focus was unmatched.
After about an hour of painstaking work, the antidote was finally ready. One by one, the blackened blood of the injured turned red again as the antidote took effect.
The Konoha ninjas watching were once again filled with awe for Tsunade. For her to neutralize such a potent poison in just an hour was nothing short of miraculous.
Tsunade's reputation spread quickly throughout the Konoha camp. The antidote was immediately mass-produced, and every Konoha ninja going out to confront the Sand ninjas was given a dose, just in case.
---
On the other side of the battlefield, Chiyo the mastermind behind the Sand Ninja's poison, was equally shocked when her poison failed again. It was clear now that Konoha had a skilled detoxification expert on their side.
As a master of poison herself, Chiyo was not one to accept defeat so easily. This sparked a contest of wits between Konoha's detoxification master, Tsunade, and Sunagakure's poison expert, Chiyo.
Chiyo continued to refine and update her poisons, releasing new strains every few days, each deadlier than the last. And while many Konoha ninjas fell victim to these new poisons, Tsunade's skill in developing antidotes ensured that the death toll was kept within manageable limits. With each new toxin Chiyo devised, Tsunade was quick to craft an antidote, rendering the Sand's puppet masters less effective with each passing day.
It became a battle between medical geniuses.
"Konoha's detoxification expert is truly impressive," Chiyo remarked, impressed despite herself.
"And Suna's puppet masters are equally formidable," Tsunade noted, as reports of Chiyo's relentless attacks reached her.
Though they had never met face-to-face, both Chiyo and Tsunade had come to recognize each other as worthy adversaries. Each was aware of the other's presence in the opposing camp and grew curious about their rival.
And so, the two villages began sending scouts to learn more about the mysterious figures behind the poison and antidote.
---
"Ninja from Konoha! Who's the one making your antidote?" Chiyo's forces cornered a Konoha ninja and demanded answers.
"Hahaha, you think I'd tell you?" the Konoha ninja replied, laughing in their faces. "Do you really think I'd betray my village for my own life?"
Betraying village secrets was not only unforgivable but also dishonorable. No ninja could bear to face their family and comrades with the shame of selling out their own.
"Just tell me a name and age, and I'll let you go."
The promise was so simple that it caused the surrounded Konoha ninja to hesitate.
Could it really be that easy? Just a name and age? That wasn't even real intel, right?
"Absolutely. I give you my word," the Sand ninja pressed.
The Konoha ninja, desperate to live, relented. He gave the name Tsunade and mentioned that she was a young woman in her twenties.
Meanwhile, Konoha also employed similar tactics and learned that Suna's poison master was a middle-aged woman named Chiyo.
Despite the respect each side developed for their enemy's skill, the war continued. No admiration for an opponent would stop the bloodshed.
---
The battlefield only grew more intense as Iwagakure's forces suffered a fate similar to that of the Sand ninjas. With Tsunade's antidotes neutralizing poison and Orochimaru's inventive weapons providing tactical support, Konoha's position strengthened. What began as a tactical disadvantage for Konoha had shifted into an overwhelming advantage.
Orochimaru had anticipated that his grenades, after the initial surprise, would become less effective, their impact comparable to that of regular explosive tags. But that didn't matter. The damage was already done. The sheer shock of facing unfamiliar weapons had given Konoha the edge it needed.
Thanks to Tsunade's detoxification prowess and Orochimaru's strategic innovations, Konoha went from being outmatched to dominating the battlefield. Suna and Iwa's forces were sustaining heavy casualties, and the momentum was clearly in Konoha's favor.
But just when it seemed like Konoha was on the verge of pushing back both the Sand and Stone forces, an unexpected twist occurred.
Hanzō of the Salamander, the feared leader of the Hidden Rain Village, entered the fray.
Angered by the ongoing war that was ravaging his country, Hanzō, known as a "demigod" among shinobi decided he had had enough. He declared war on all three major nations simultaneously, proclaiming that he would not tolerate the destruction of his homeland any longer.
With a wave of his hand, Hanzō mobilized his forces, making it clear to Konoha, Iwa, and Suna that the Hidden Rain Village would no longer stand idly by.
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