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21.2% The Ultimate Host / Chapter 366: Prince Of Darkness

Chapitre 366: Prince Of Darkness

Dokan Mountain, Dokan Temple.

Dark refused to believe that his master was dead. Fuma showed him the proper way of the deathly ninja. The reason they called Dark because he was blind. He could"t see anything. Both of his eyes were white. He was born blind. He was born with LCA. (For those who don't know what LCA is.)

Leber congenital amaurosis (LCA) is a rare genetic eye disorder. Affected infants are often blind at birth. Other symptoms may include crossed eyes (strabismus); rapid, involuntary eye movements (nystagmus); unusual sensitivity to light (photophobia); clouding of the lenses of the eyes (cataracts); and/or a cone shape to the front of the eye (keratoconus). LCA is usually inherited as an autosomal recessive genetic condition.

Signs & Symptoms

Children born with LCA have light-gathering cells (rods and cones) of the retina that do not function properly. Absence or reduction of the electrical activity of the retina is always observed and is necessary for the diagnosis of LCA.

A decrease in visual responsiveness at birth is the first sign of the disease. Often the child will poke, press and rub the eyes to stimulate the retina to produce light (Franceschetti's oculo-digital sign). This activity may cause the eyes to become sunken or deep-set (enophthalmos).

Other symptoms may include strabismus; nystagmus; photophobia; cataracts; and/or keratoconus. In addition, some infants may exhibit hearing loss, intellectual disability, and/or developmental delay.

Specific types of LCA have been defined based on the causative gene. Some types are associated with little change in vision over time (stationary disease) while others become more severe over time (progressive disease).

Causes

LCA is a monogenic disease and at least 27 genes are implicated. Changes (mutations) in these genes can account for about 80-90% of diagnosed cases of LCA. The genes responsible for the remaining 10-20% of diagnoses are not known. LCA is usually inherited as an autosomal recessive genetic condition. Twenty-four of the genes associated with LCA cause only recessive disease. Two genes (IMPDH1 and OTX2) are known to cause a dominant disease. One gene (CRX) is known to cause either dominant or recessive disease, depending on the specific mutation.

Recessive genetic disorders occur when an individual inherits two copies of an abnormal gene for the same trait, one from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease but usually will not show symptoms. The risk for two carrier parents to both pass the defective gene and have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%. The risk is the same for males and females.

There are about 20,000 different genes in a human and all individuals carry one copy of several abnormal genes. Parents who are close relatives (consanguineous) have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.

In rare cases, LCA is inherited as an autosomal dominant genetic disorder. Mutations in three genes, CRX, IMPDH1, and OTX2 are currently known to be associated with this type of LCA.

Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary to cause a particular disease. The abnormal gene can be inherited from either parent or can be the result of a new mutation in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy. The risk is the same for males and females.

Affected Populations

The prevalence of LCA has been estimated to be 1-2/100,000 births. This disorder affects males and females in equal numbers.

Related Disorders

Symptoms of the following disorders can be similar to those of Leber congenital amaurosis. Comparisons may be useful for a differential diagnosis:

Loken-Senior syndrome is a rare autosomal recessive genetic disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. (For more information on this disorder, choose "Loken-Senior" as your search term in the Rare Disease Database.)

Joubert syndrome is an autosomal recessive genetic disorder that affects the area of the brain that controls balance and coordination. This condition is characterized by a specific finding on an MRI called a "molar tooth sign" in which the cerebellar vermis of the brain is absent or underdeveloped and the brain stem is abnormal. The most common features of Joubert syndrome are lack of muscle control (ataxia), abnormal breathing patterns (hyperpnea), sleep apnea, abnormal eye and tongue movements, and low muscle tone.

Dark wished for sight. He wanted to kill the one who killed his master. However, he would have to keep the clan in check.


Chapitre 367: New Leader Of The Nightmare's Gulch

Everyone looked at Dark as if he was a big fat joke. One of the ninja's decided to say something. " What makes you think that we will listen to you just because Fuma Kotaro hasn't returned?" "I do not expect you to listen to me." "But there will be consequences if you don't. "

The ninja immediately closed his mouth. Nobody dared to mess with Dark. Everyone in the entire Nightmare's Gulch knew that Dark was extremely dangerous. Fuma thought him things stay Fuma never thought the other ninjas. "Since you now are all being cooperative now I have some things to say."

"First of all, I am now the rightful ruler of this clan." "You will all do as I say." "You will do what I tell you." "If you don't, I give you permission to overthrow me." The same ninja from before walked in front of his comrades holding a Kuni tightly in his hand.

Even though Dark couldn't see he could read and sense his opponent's movements. The ninja threw the Kuni at Dark"s face. The Kunai sliced three layers of flesh off his face gushing blood all over his clean ninja attire. The ninja began smiling. "It looks like my calculations were correct."

"You are just a useless blind motherfucker." The ninja pulled out three Kunai"s at Dark. Dark could hear the wind of the Kuni"s. He dodged the Kuni"s without moving one hair on his body. He then pulled out Shuriken throwing it at the ninja.

The Shuriken chopped off the ninja's hands gushing blood all over the place. The ninja dropped on the ground screaming. Dark jumped from the rock he stood on picking up his Shuriken which was lodged in the ground. He placed it in his foster cracking his neck. "Anyone else?"

He didn't hear anyone saw anything. "That's what I fucking thought." Now before I was interrupted, I was trying to say this." "I want half of you to go to this realm called Earth and kill Lynx A.K.A The Ronin." When the other ninja heard this they thought in their minds that Dark was sending them on a suicidal mission.

They all went on dangerous missions in the past, but Lynx was also trained by Fuma Kotaro. He was the one who murdered Amon. "You all will be headed to Earth three days from now." Dark headed to his chambers. In his chambers, he had weapons and food all over the place.

He picked up a sweet roll and a piece of cheese. He sliced the sweet roll open and placed the piece of cheese inside. He took a while bite out of the sweet roll and cheese sandwich. He then picked up Ale guzzling it down. He was blind but he didn't act like he was blind.

He acted like the average normal person who could see. When he was about to pick up another sweet roll, he thought about the first time he met Fuma Kotaro. He placed the sweet roll back on the ground and stepped on it. Icing and milk oozed out of the sweet roll. He laid back in a chair and close his white blinded eyes.

Earth, The Ronin's Location, Manhattan.

The Ronin finally made it to Manhattan. Grey told him that Kuma was still in Manhattan. The Ronin placed his hand on the ground channeling aura around his fist. The Ronin instantly found where Kuma was hiding. The reason Grey told The Ronin to kill Kuma was that he also deserted his post.

Kuma's, Location.

Kuma was in the Grand Central Terminal. There he took a job as a bouncer at club Outrage. He made a good amount of money. Twenty-two dollars an hour. Club Outrage had a lot of money to spare. The club made over ten grand a day. Some days the clubs even made twenty grand.

After Kuma's shift was finish he was going to eat dinner. A dinner named Last Resort. When he entered Last Resort everyone stared at him as if he was a freak of nature. He sat down in a seat close to the window. A waitress walked up to him with a scared look on her face.

"Good night... Sir." "What will it be tonight?" Kuma picked the menu and observed it. "I will have nachos, five grilled cheese sandwiches, potato skins with no sour cream, burgers, and fries with the meat well cooked and the cheese melted, spaghetti and meatballs with alfredo and mozzarella cheese, fried chicken and rice, mashed potatoes with a lot of butter and gravy, and last I will have some tuna sandwiches with mayonnaise and a lot of pepper." The waitress looked at Kuma like he was glutton. "What will you have to drink?"

Two lemonades and five bud lights. "Please wait patiently while the chefs cook your food." Another waitress brought him appetizers. The appetizers were glazed donuts. He ate all five donuts without savoring the flavor.

When Kuma was looking at the dessert menu, The Ronin was watching his every movement carefully. The Ronin held a Kunai in his hand tightly. He threw it at Kuma who wasn't aware. Kuma dodged the Kunai at the last minute. The Kunai went through the wall killing one of the chefs.

One of the waitresses started screaming. Kuma looked through the window which had a hole in it. The Ronin then threw five Shurikens at Kuma. Kuma dodged the Shurikens which killed the customers waiting for their food. Kuma walked out of the dinner and saw The Ronin who was camouflaged.

The Ronin got away from his hiding spot landing in the ground holding two Kunai in his hands. Kuma looked at The Ronin whose body was covered in black muck. The Ronin threw both Kunai at Kuma's chest. The Kunai bounced off Kuma's chest. Kuma punched the ground and threw it at The Ronin who rolled out of the way throwing a Shuriken at Kuma's neck. A thin layer of blood came out of his neck. Kuma turned his hand into a fist punching The Ronin in the chest making him smash into a fire hydrant coughing up blood.


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