Chapter 5: Dead Island 2 : Plot

Tisha, who apparently kills them, only for them to be revived to Konradt. She explains to the Slayers that she, her followers, and the Slayers are a new type of humanity dubbed Numen, who can assimilate the infection, called the Autophage, while retaining their minds and gain a telepathic hive mind with other Numen. Before leaving, she warns the Slayers that Reed is not actually searching for a cure. The Slayers return to the Serling Hotel to confront Reed, to find out he has fled with Tisha to a lab on Hollywood Blvd and that he was responsible for the Autophage outbreak in LA.

Furious at constantly being lied to, the Slayers gather together Emma, Sam, and helicopter pilot Patton with the intention of stealing Reed's helicopter and leaving the city. They reach Hollywood Blvd, where Sam begins to succumb to the Autophage, his immunity deteriorating. The Slayers go on ahead and confront Reed, who admits that he released the Autophage in LA in order to filter out Numen, explaining that the Autophage is not a plague, but a part of humanity's DNA that is hard-coded to wipe them all out at a predetermined time; the Numen, who he considers either anomalies or "puppets" of the Autophage, were his only way to find a method to neutralize it. He gives the Slayers a single dose of Autophage cure, and reveals that Tisha also carries the cure in her body as he secretly injected her with Numen blood prior to birth in order to harvest the cure for the rest of her life. Reed succumbs to the Autophage, forcing the Slayers to kill him while Tisha flees.

The Slayers return to Emma, Sam and Patton and administer the cure to Sam, saving his life. The Slayers decide to stay behind in LA to find Tisha as well as help the other survivors trapped in the city. As Emma, Sam and Patton escape the city, Konradt and her followers watch over the Slayers as they fight another horde of zombies.