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After being caught by Drake and almost killed, Doctor Colorado injected himself with deadly drugs made using the mutated blood of failed clones of Emil's alien race, this, instead of just giving him powerful psychic abilities, infected him with the cancerous blood cells within these clones, which rapidly merged into his body!
Eventually, against his own will, the Doctor ended becoming a monstrosity beyond his wildest imagination, or even that of Drake. His body constantly grew larger and larger, neverendingly multiplying cancerous cells everywhere.
His brain also increased in size ridiculously, to the point his psychic powers exploded in strength! However, the Doctor was no more than a screaming, agonizing abomination, with the small head of a child whose blood cells belonged from growing from his forehead.