In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
Perhaps they would start off as strangers and then become friends through a shared struggle. For example, they might both be targeted by a new and dangerous enemy. As they fight side by side, they start to understand each other's motives and values. Giorno might learn from Joseph's years of combat experience, while Joseph could be inspired by Giorno's fresh perspective and determination. They could also have some humorous exchanges, with Joseph making jokes and Giorno having a more deadpan reaction.