Who could be the main characters in a 'Venom x Mass Effect fanfiction'?

Well, Venom could be an unexpected addition to the Mass Effect universe. It could be a relic from an ancient civilization that is discovered. Maybe it was created as a weapon against a powerful enemy in the past. In fanfiction, it could be found on a derelict ship or an uncharted planet.

It could be a mix of characters from both universes. There might be classic WW2 soldiers like Patton or Eisenhower, but with a Mass Effect twist. Maybe they have some kind of exposure to Mass Effect technology that gives them special abilities. Also, there could be Mass Effect characters like Shepard who are somehow transported to the WW2 era.

Obviously, Tevos is a main character. She's a significant figure in the Asari government. And then there are the OCs (original characters). These can be a wide variety of beings. It could be a human soldier who gets involved in Asari politics because of some incident related to Tevos. Or an alien scientist who teams up with Tevos to study an ancient Prothean relic. Each OC brings their own backstory, skills, and motives to the story.

There might be a human scientist who is at the forefront of some revolutionary discovery. This character could be trying to unlock the secrets of an ancient alien technology that has the potential to change the course of humanity's future in the fanfiction.

One idea could be that Venom's symbiotic nature interacts with the biotics in the Mass Effect universe. Maybe the symbiote gives a character enhanced biotic abilities that are unique and unheard of. For example, instead of just pushing or pulling with biotics, they can create a sort of living shield made of the symbiote's substance.

Some fanfictions focus on the idea of the symbiote being a sort of 'alien within an alien' in the context of Mass Effect. It could be hunted by Cerberus for study, thinking it's a new type of alien life form. The Venom symbiote's need for a host and the way it changes the host's personality could lead to some really complex and engaging storylines. For example, if a Krogan became the host, how would the combination of their natural aggression and Venom's influence play out? It could be a really wild and exciting read.

Well, it could lead to some interesting self - reflection. For example, Tali might be intrigued by how fans view her relationship with the other characters. Liara could be either flattered or a bit concerned about how her character is portrayed in the fanfic, especially in terms of her romance with Shepard.

Shepard could be a main character. Given their experience in uniting different species and facing great threats, they would be a natural fit in a world war scenario. They could lead a coalition against a new enemy.

The main characters are Naruto and Jack, but the fanfiction could also introduce new characters that are a blend of the two universes. For example, there could be a character who has both chakra - like Naruto - and biotic abilities - like Jack. This new character could be the result of some experiment gone wrong or a natural occurrence in the combined universe of the fanfiction. And of course, there would be various antagonists, such as the usual bad guys from the Mass Effect universe who see Naruto as an unknown and dangerous variable, and perhaps some of Naruto's enemies from his own world who have also found their way into the Mass Effect universe.

Shepard from Mass Effect could be a main character. They could lead the XCOM forces in a joint mission against a common enemy. Their leadership skills would be very useful in coordinating the two very different groups.