In a reverse Spider - Man story, the relationship with the police could be reversed too. Normally, Spider - Man has an uneasy but mostly positive relationship with the cops. But if Peter is causing trouble, the police would be actively trying to catch him. Also, his relationship with other superheroes in the Marvel universe, if they exist in this story, would be completely different. They would likely view him as a threat and try to stop him rather than collaborate with him as they might in the traditional story.
His relationship with Aunt May would likely become more strained as she becomes overprotective, fearing she could lose him too. With his friends at school, he might become more distant as he is preoccupied with superhero duties. He could also be more cautious around MJ, not wanting to put her in danger in the new, more dangerous world.
His relationship with Mary Jane would likely become more normal. Instead of constantly worrying about his safety while he's out fighting crime, they could focus on building a more traditional family life.
His relationship with Mary Jane would likely be affected. She might sense that something is different about Peter (Spider - Man). He could become more distant or moody because of the symbiote's influence, and this could cause some strain in their relationship.
If Black Cat and Spider - Man switched bodies in a fanfiction, their relationships would be a mess. Enemies like the Green Goblin might take advantage of the situation. He might think that Spider - Man has finally turned to the dark side if he sees Black Cat's behavior in Spider - Man's body. As for their allies, they'd be constantly second - guessing who they're really dealing with. On a more personal level, if they have any romantic feelings for each other, those would be tested. They'd have to communicate in a different way, since they're not in their own bodies. It would be a rollercoaster of emotions and misunderstandings as they try to keep their relationships intact while in the wrong bodies.
Their relationships would change significantly. For instance, their friends might be very confused at first. Spider - Man's friends would see the Wasp acting differently in his body, and vice versa. Their romantic relationships, if any, would also be affected. They would have to explain the situation to their loved ones, and it could lead to some awkward or comical moments.
In a time travel scenario for Spider - Man Homecoming fanfiction, Peter's relationship with Flash Thompson could take an interesting turn. If he goes back in time, Flash might not be the bully he is in Peter's original time. Peter could end up befriending him, which would change the whole school dynamic for Peter. And if he travels to the future, Flash could have had a complete change of heart and be an ally. Peter would have to adjust to this new - found friendship or alliance with Flash, which would be very different from what he's used to.
Let's start with the Avengers. In Spider - Man's body, Jane would interact with the Avengers in a unique way. She would bring her scientific knowledge to the table, which could be very useful in some situations. However, her different personality might cause some friction. For example, Iron Man might be intrigued by the new 'Peter' but also a bit annoyed at the different approach. Captain America might see the change in 'Peter' as a sign of him growing up in a different way. On the other side, Spider - Man in Jane's body would have to deal with Asgardian friends and foes. He would befriend some of the more adventurous Asgardians, but also face the jealousy of some who don't like this 'outsider' in Jane's body. Overall, their body swap would create a lot of chaos and interesting changes in their relationships with other characters.
It would likely strain his relationship with Iron Man. Since Iron Man supported the Sokovia Accords, Spider - Man, if he's against them, would find himself at odds with his mentor. Their interactions would become more tense and filled with ideological differences.
One idea for a reverse Spider - Man story is that Peter Parker is not the main character at all. Instead, it's someone who hates Spider - Man. This person discovers a way to reverse Spider - Man's powers. As Spider - Man loses his powers bit by bit, the city starts to fall into the hands of real villains. And the person who caused this has to face the consequences of his actions and eventually realizes that Spider - Man was actually a necessary hero.
The Infinity Stones would likely put a strain on Spider Man's relationships. His friends and family might be worried about the power he holds. For example, Aunt May might be constantly afraid that he'll get hurt or that the power will change him for the worse. His relationship with MJ could also be affected. She might be in awe of his new power, but also a bit intimidated.