There could be a demonic entity in the new world. It might be awakened by Gilgamesh's arrival. This entity is used to having its way in the world and sees Gilgamesh as a new obstacle. It could possess other beings to attack Gilgamesh and use the chaos of the new world to its advantage.
The devils who oppose Gilgamesh's presence in the Highschool DxD world could be main antagonists. They might see him as a threat to their power and influence in the school.
It could be some of the traditional power - hungry ninja clans who oppose Naruto's new world order. They might see his attempts at global control as a threat to their own interests and try to undermine him.
In a more futuristic world, a corrupt corporate leader could be the bad guy. He wants to use Naruto's abilities for his own profit, like making Naruto fight in illegal gladiator - like battles for entertainment. If Naruto refuses, he threatens to harm the people Naruto has grown to care about in this new world.
It could be the Ministry of Magic if they turn corrupt or power - hungry. They might see Harry and Hermione as a threat to their authority and try to stop them at all costs. Another possible antagonist could be a dark wizard or group of dark wizards who are using the chaos in the wizarding world to their advantage and Harry and Hermione are the only ones standing in their way.
It could be a group of corrupt business people. They use their wealth and influence to manipulate the city's economy and politics for their own gain. Naruto, with his sense of justice, would oppose them. For instance, they might be trying to close down a community center that helps underprivileged kids, and Naruto steps in to stop them.
It could be some of the old - school ninja clans who are against the new order Naruto and Hinata are trying to establish. They might see their rule as a threat to their traditional power and influence.
A new student who is overly competitive and tries to undermine Ginger at every turn could be an antagonist. This student might be jealous of Ginger's popularity or her skills in a particular area like academics or a club activity.
A group of female ninjas who oppose Naruto's presence in their world could be antagonists. They might believe that his arrival will disrupt their way of life and power structures. For example, a powerful all - female clan that has long held sway in the ninja world might see Naruto as a threat to their dominance.
In a magical world, a powerful sorcerer could be the antagonist. This sorcerer views Tony's attempts to blend technology and magic as an abomination and will do everything in his power to stop Tony from spreading his ideas and inventions. He might even try to steal Tony's technology for his own dark magic purposes.
The Yonko would definitely be major antagonists. Since Luffy is in the New World, the likes of Kaido or Big Mom would be natural choices. Their vast power and influence would pose a great threat to Luffy and his crew.