Maybe the main antagonist is a jealous rival. This rival is envious of her abilities and status, so she uses a forbidden magic to turn her into a card. The rival then tries to take her place in the story, but her friends start to suspect something is wrong and begin to investigate.
It could be a powerful dark wizard or sorcerer who has a grudge against angewomon or wants to use her power in some way, so they turn her into a keychain.
It could be a villain who wants to steal all the cookies in the world. This villain sees Android 18's new - found love for cookies as a threat to his plan, so he tries to stop her from spreading the joy of cookies.
There could be a group of mean - spirited fairies. They see Sakura as an intruder in their territory, which might be a beautiful garden that Sakura often visits. To drive her away, they use their fairy magic to turn her into a cat, thinking that she will be less of a threat in that form. And they keep thwarting her attempts to turn back into a human throughout the fanfic.
A powerful and jealous digimon who has always been envious of angewomon's status and power could be the main antagonist. They might have found a way to turn her into a keychain to get rid of her.
Perhaps the main antagonist could be a dark magic user who was the one responsible for turning Harry into a girl in the first place. Their goal might be to disrupt Harry's life and his role in the fight against the dark forces. This antagonist could continue to create obstacles for Harry as a girl, like trying to prevent him from getting the help he needs to change back or causing trouble for his friends who are trying to support him.
One possible storyline could be that she is turned into a card by a powerful villain as a way to imprison her powers. Her friends then embark on a quest to find the magic to turn her back. Another could be that it was an accidental spell by a novice wizard that changed her, and she has to learn to communicate from within the card to get help.
A dark wizard from the past whose secrets are being unearthed because of Hermione's exploration of the Chocolate Frog Card could be the main antagonist. Maybe the wizard was banished long ago and doesn't want his secrets revealed. He could start to influence events at Hogwarts through dark magic, trying to stop Hermione from learning more about him. For example, he could possess other students or create dangerous obstacles in Hermione's path.
A powerful and jealous Digimon could be the antagonist. Maybe a Digimon that has always envied Angewomon's grace and power. This Digimon finds a way to turn her into a doll to get her out of the picture and claim her status in the Digital World.
It could be a rogue Team Rocket member. Maybe they got their hands on a powerful new device that was meant to capture Pokemon but malfunctioned when aimed at Misty and turned her into stone instead. Now they're trying to cover up their mistake and keep Ash and the others from finding out the truth.
The Green Goblin could be a great antagonist. His chaotic nature and advanced weaponry would pose a serious threat to both Spider - Man and She - Venom. He could be after a new power source related to the symbiote, which would bring him into conflict with our heroes.