His friends would be extremely worried. Sakura, for instance, would likely try to use her medical skills to help him and also try to figure out why he's doing it. She might be angry at first for him harming himself but then become very concerned. His relationship with Sasuke could also change. Sasuke might see Naruto's self - harm as a sign of weakness or, on the other hand, it could make him more empathetic towards Naruto as he has his own inner demons.
If Naruto has a physical disability like a broken arm that doesn't heal properly in fanfiction, his friends like Sasuke and Sakura would need to step in and help him more. Sasuke might be more protective, which could change their dynamic from a competitive one to a more collaborative one. Sakura could use her medical skills to try and find a way to heal him, which would bring them closer. His relationship with his teachers, like Kakashi, would also change as they'd have to adjust their training methods.
His relationship with his sensei, like Kakashi, could become more complex. Kakashi would feel guilty for not being able to protect Naruto from the experiments. And Naruto might start to question Kakashi's ability to keep him safe. This could lead to a strain in their relationship at first, but later they could grow closer as Kakashi helps Naruto recover from the trauma of the experiments.
Enemies would definitely be more cautious around Naruto. Those who once underestimated him would now fear his golden chakra. This could lead to some enemies trying to find weaknesses in it. Meanwhile, Naruto's new power might also attract the attention of mysterious characters who want to guide him in using it, which could cause some friction with his existing relationships as he has to decide who to trust.
When Naruto snaps at Konoha in fanfiction, it has a complex impact on his relationships. With his closest friends like Sakura, she might initially be confused and try to talk some sense into him. But if Naruto is resolute, it could create a divide. His relationship with the village leaders would turn sour, as they see him as a threat to the village's stability. However, some outcast ninja in Konoha might see Naruto as a kindred spirit and side with him, which could also lead to new alliances and friendships.
Well, when Naruto has multiple affinities in fanfiction, it really shakes up his relationships. Imagine if he has lightning affinity. Lightning - style ninjas may see him as a kindred spirit and form closer bonds with him. On the other hand, some characters who are used to Naruto having a more limited set of abilities may feel threatened. This can lead to some characters trying to undermine him, while others will be drawn to his new - found potential and seek to be his friend or mentor.
Some characters might be afraid of the wasp hive and avoid Naruto because of it. This could cause a bit of a rift in his friendships at first.
His overprotectiveness towards his sibling might make his friends a bit cautious. They might not want to involve Naruto's sibling in any dangerous missions or activities for fear of angering Naruto. For example, Kakashi might be more hesitant to let Naruto's sibling go on a mission with the team.
If Naruto can shapeshift, it might make some characters more distrustful at first. They would be unsure if it's really him or an imposter. For example, Sakura might be more cautious around him until she can confirm it's the real Naruto.
Well, in such fanfictions, Naruto's stupidity might make some characters more protective of him. For example, Sasuke could be more annoyed at first but gradually become more concerned as he realizes Naruto's good heart beneath the 'stupid' actions. And Sakura might scold him more often, but still care for him in a sisterly way. It can create some interesting dynamics in their friendships.
His friends would probably be concerned at first. They know Naruto is good - hearted, but this new power from the Gedo Mazo is something unknown. However, they would also likely try to support him. Sakura might be worried about his physical and mental state, while Sasuke could be more interested in how Naruto plans to use this power. Naruto's relationships would become more complex as he has to prove to others that he can control this new power and still be the same Naruto they know and love.