One plot idea could be a story where Kisame and Itachi are on a mission together in a mysterious land. They encounter various challenges that test their loyalty to each other and their organization. As they face these difficulties, they start to understand each other on a deeper level, sharing their past traumas and dreams. This could build a strong bond between them without any inappropriate content, focusing more on their friendship and mutual respect.
Another plot could revolve around Itachi and Kisame having a philosophical debate during a long journey. Since Itachi has his own complex moral code and Kisame is more straightforward in his loyalty to the Akatsuki, they could discuss the meaning of loyalty, power, and the end goals of their organization. This could lead to a deeper understanding between them or even a rift, depending on how the story unfolds.
One idea could be that Fem Kisame is a reformed Akatsuki member who teams up with Naruto to take on a new threat to the ninja world. They start off not trusting each other but gradually learn to respect and rely on one another as they face various challenges together.
A really interesting plot could be a time - travel fanfiction. Suppose Sakura somehow travels back in time and meets a younger Kisame. She tries to change his path, knowing the future he will have. This could involve a lot of complex character development as Sakura has to deal with the differences in their values and the knowledge she has of his future actions.
One interesting plot could be Kisame and Naruto teaming up accidentally during a mission against a common enemy. They start off distrusting each other but gradually learn to respect each other's skills.
A story about them swapping bodies for a while could be really fun. They have to adapt to each other's abilities and lives while trying to figure out how to swap back. This would involve a lot of character exploration as they experience the world from the other's perspective without any adult - themed content. They might also learn new things about each other and grow as characters.
One interesting aspect is the re - imagining of the Akatsuki dynamic. With a female Itachi, the power balance and the way she is perceived within the group could be different. Her relationship with Kisame could then have an impact on how they are both seen by the other members. Another aspect is the potential for different story arcs. For instance, a female Itachi might have her own personal goals that are related to her femininity, like protecting other female characters or using her unique perspective to change the Akatsuki's goals in a more nurturing way. And this would all play out in her relationship with Kisame.
One idea could be a story where Kisame and Sakura are forced to team up during a mission in a strange, new land. They start off distrusting each other but gradually learn to respect one another's skills. For example, Kisame is impressed by Sakura's medical ninjutsu when she heals him from a near - fatal wound. Another plot could be set in an alternate universe where they are both students at the ninja academy together, and their different personalities lead to some comical and also some heartfelt moments as they grow up.
A possible plot could be them going on a journey together to discover more about their clan's past. They could face various challenges and enemies along the way, and through these experiences, they grow closer as siblings. Another idea is that Fem Itachi could be training Sasuke in a new and unique jutsu that she has developed, and they have to work together to master it.
A fanfiction could be written where Sasuke returns to the village earlier than in the original story. Itachi, still alive in some way, along with Sakura, helps Sasuke reintegrate into the village. They all work together to overcome the distrust of the villagers and also face new threats together. This would explore their relationships in a more positive and collaborative light. It would also show how their different skills, Itachi's strategic mind, Sakura's medical and combat skills, and Sasuke's power, could be combined to protect the village and each other.
One possible plot could be that a powerful and mysterious ninja casts a spell on Itachi as part of a revenge plan against the Akatsuki. This results in the MPreg situation. Kisame and Itachi then have to embark on a journey to find a way to reverse the spell. Along the way, they face various challenges and also discover new things about their relationship and themselves. For example, they might find that they are more in love than they thought and that they are willing to sacrifice a great deal for each other and the unborn child.