Maybe Remus did something that broke a major rule or hurt someone's feelings, and that's why he got a howler. The sender might be a teacher, a friend, or even a family member.
Well, it could be that someone was really angry with him and sent it to express that rage.
His mother is a likely sender. She could be worried about Remus and send a Howler to remind him to take his Wolfsbane Potion regularly or to be more cautious around others. Mothers are often protective, and in the wizarding world, a Howler is a rather forceful way to get your point across.
Perhaps the Marauders wanted to warn Harry about something important and thought a howler was the best way to get his attention. It could also be a part of a complex magical game or challenge among them that accidentally involved Harry.
Well, it could be that she broke some important rule or did something that really angered another character, and they decided to send a howler to give her a piece of their mind. Or perhaps it was a misunderstanding that led to the howler being sent to her.
Maybe it happened because he made a big mistake in a magical experiment or broke a strict school rule. That might have triggered a howler being sent to him. The possibilities are endless in fanfiction!
In the 'Remus gets a Howler' fanfiction, the Howler could be a misdirected one. It was actually meant for someone else but got sent to Remus by mistake. This could lead to all sorts of comical situations as Remus tries to figure out what to do with it. He might initially think he's in trouble for something he didn't do and start to worry. Then, when he discovers it's a mistake, he has to find a way to return it to the right person without getting into more trouble himself.
Voldemort might initially be furious. He's not used to being challenged in such a blatant way. He could try to destroy the Howler immediately in a fit of rage.
He might be very embarrassed. Howlers are known for delivering their messages in a rather loud and public way. Draco, who is used to maintaining an image of superiority, would find it humiliating to have his family's business aired out in front of his classmates.
He might be initially embarrassed, especially if he receives it in a public place like the Great Hall.
The fanfiction usually shows Snape being quite shocked and embarrassed when he gets the howler. It might lead to some interesting character developments and interactions.
Hermione could be very hurt. She respects Mrs Weasley a great deal, and to receive such an angry message from her would be a big blow. So she might cry and isolate herself for a while to think about what she did wrong and how to make it right.