It could be a rival cowboy named Orochimaru. He's jealous of Sasuke's skills and the fact that Sakura is with him. Orochimaru might try to steal Sasuke's horse or sabotage their quests for supplies. He could also spread false rumors about them in the small Western towns they pass through, causing trouble for them.
Maybe a group of outlaws led by Kabuto. They see Sasuke and Sakura as easy targets. They try to rob them of their valuables, which include a special lemon - scented medicine that Sakura has made. This medicine is important for a sick child in a nearby town. So, Sasuke and Sakura have to fight off these outlaws to protect the medicine and continue their journey.
The main antagonist could be a land - greedy rancher named Danzo. He wants to take over all the land in the area, including the land where the lemon trees grow that Sakura loves. He tries to drive Sasuke and Sakura out of the region by any means necessary, setting up traps for them and hiring thugs to attack them.
If you want the clearest chapter reference, go to Chapter 135. Early on, The sun blazed down mercilessly, but thankfully, the path to the mountain...; later, the chapter leans on Zhao Lang was also very humorous, and even the usually stoic Jiang Li....
Look to Chapter 128 for the clearest answer. It begins with Still hungover, Huo Ziyang had just awakened from a blurry dream when his..., keeps building through He clicked his tongue in annoyance and picked up the phone., and lands on There had been no shortage of Weibo posts criticizing Jiang Li.
The best chapter pointer here is Chapter 145, "Director Sun, You Haven't Paid for the Meal Yet". It opens with Chixia Village was located in a remote area with a backward economy, so... and closes on What about it?" "That's unfortunate," said Jiang Li indifferently..
Chapter 167 is the strongest chapter-level answer because it starts from By the experimental field, Qi Tianyu was quite helpless as he watched Wen... and follows through on Even when getting into the car, Qi Tianyu was still savoring the moment in....
Look to Chapter 146 for the clearest answer. It begins with Director Sun: "???" Jiang Li smiled and said, "In the past, the show crew..., keeps building through But most of the dishes tonight are made by the villagers., and lands on That way, they could maximize the traffic for their live.
Chapter 139 is the strongest chapter-level answer because it starts from Wen Jiaojiao's live stream was inundated with a wave of question marks. and follows through on The audience in the live stream didn't know about Wen Jiaojiao's inner....
Chapter 127 is the strongest chapter-level answer because it starts from Witnessing Jiang Li leave with a bucket, Jiang Yan refused to admit... and follows through on He Yun, who chose the codonopsis, became the one with the most challenging....
Look to Chapter 117 for the clearest answer. It begins with Fragrant and cloyingly sweet potatoes and corn were out of the pot, and Qi..., keeps building through The searing heat made him grimace in pain, but he didn't let go, and he..., and lands on Since entering puberty, his mother had exerted.
The best chapter pointer here is Chapter 141, "The Recruitment Contest!". It opens with It had happened in the afternoon when Aunt Ying's son and daughter heard... and closes on Jiang Li couldn't help but laugh and cry..
The best chapter pointer here is Chapter 120, "Jiang Li Can Actually Do Acupuncture?!". It opens with Facing the sudden and somewhat strange request from Jiang Li, Director Sun... and closes on Drink this." Wen Jiaojiao looked at the half cup of thick substance:....