After hearing Isao's words, Subaru, Kasumi, and the Realizers of their organization were furious. Even though he said that the League of Heroes didn't use humans as experiments, they still did after the serum finished. They couldn't accept that because they thought what the League of Heroes had done was inhumane. The Realizers wanted to say something to him, but Isao opened his mouth first.
"Please listen to my words before you get mad at me! They used the serum on their own accord; we have their approval. So the League of Heroes never forces them, let alone threatens them. Those people want to be the object of experimentation to multiply their power. They had been stuck as a low-level Realizer for a long time and wanted to increase their phase to become a high-level Realizer." Isao quickly explained before the Realizers from the Holy Union and Belial Alliance got mad at him.