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Earth, year 2037.
After the incidents that brought the end of the test subject 0, Miranda, the organization led by Ivan Wesker didn't waited for someone new with her capabilities to show up randomly.
They simply decided to create a new one themselves.
Using the advanced technology which they held thanks to their deals with North Korea and China, and the large funds they got from these two countries hopping to get a slice of the cake of the bioweapons that Ivan Wesker was creating, the organization quickly began a malicious and aberrant experiment.
They began to simply create life themselves, someone compatible from the very beginning would be greatly fitting of their experiments, and they had realized that if they couldn't find someone, they had to simply create it.
Using the modified DNA of Miranda, and the preserved frozen blood, skin tissue, muscle tissue, and bone marrow from her spine, a truly aberrant creation began.
Check "The Protagnist's Sister Is Actually the Strongest"!