Humans were always known to create something but whatever they created against special beasts it was useless. That was to say, Nuke can never kill a dragon, but if the nuke has some essence from enchantment or influence from some beast bloodline or even the blessing of a tamed beast, that is when the dragon can be killed.
There were other solutions but the above were mainstream and well-known. However, it was never enough. Humans might be able to proliferate faster than dragons but not as fast as Sapient Ants, a fierce race of Ant.
And a single dragon can massacre millions in just an hour. So, the greatest solution humans ever got was Temporal Ability, the ability to function with aspects of time.
No one knows how it came but many speculated it was a gift from the world to balance the equation.