Runes were the oldest writing on heaven and earth and it was not one of the many.
During ancient times, cultivation with runes was once very popular with many schools but until this day, there was only Zhengyi Sect which continued on this path. The rest of the schools were destroyed. While Zhengyi Sect attempted to reach Huandan by condensing Talisman seeds, it was different from the plain Dao of Talisman from ancient times.
The cultivators of Tianhua Continent did not care about talismans, comparatively speaking, because Jiang Hanyan imprinted the talismans Shen Lian had laid down into her mind and heart.
These runes were only the cloud and thunder seal script and not the seal of dragon and phoenix script, hence it would not grant one the power of those who were beyond humans, the holy deities. They were not as terrifying as the heavenly script, which was meant to understand the deepest principle of the universe, a form of Daoist writing.