Deku might be completely shocked at first. Since Bakugou has always been so aggressive towards him, he would never expect such a confession. He might just stand there, mouth agape, not knowing what to say.
As of now, Deku is very much alive in the manga. The plot hasn't reached a point where he meets such a fate. Usually, main characters like Deku have significant story arcs and aren't easily killed off.
He might cry a lot. Deku is very emotional, and being cheated on would be a very painful experience for him. He could also get angry, which is rare for him, but this situation would be so unjust that he might not be able to hold it in. He'd probably start to question his self - worth too, thinking that there was something wrong with him that made his partner cheat.
The main differences are in their expressions and some minor details of personality. In the manga, Deku might seem a bit more intense, while in the anime, he's sometimes presented a bit softer.
Deku might be initially shocked. He's used to Bakugou's aggression, but an actual injury is different. He could be in pain and disbelief at first. Then, he might try to downplay it, especially if he doesn't want to cause trouble for Bakugou, because Deku is generally a very forgiving character.
In the manga, Deku experiences various ups and downs. He not only becomes stronger physically but also matures emotionally as he takes on greater responsibilities. There are also many unexpected plot twists that shape his journey.