One possible villain could be Doctor Octopus. He might be back with some new and improved mechanical arms, and he wants to prove that he's the superior scientist and villain by defeating both Spider Man and Spider Girl.
The Green Goblin is a main one. He's always causing trouble for Spider - Man. Norman Osborn, as the Green Goblin, has a complex relationship with Peter Parker, which makes their battles even more interesting.
The main villains in the Cosmic Spider - Man story are quite interesting. Firstly, there's Mysterio. In this story, he uses his illusions in a more cosmic - level way to deceive Spider - Man. He teams up with some other villains to try and bring down Spider - Man. Then there's Sandman, who has been corrupted by a cosmic force and is now a more menacing foe. Another big villain is Carnage. He has a new form that is powered by a dark cosmic energy. All of these villains pose different threats to Spider - Man and his new cosmic - powered self.
Some of the main villains in Insomniac Spider - Man 2 are Kraven the Hunter and Venom. Kraven is a formidable foe known for his hunting skills, and Venom brings his own unique set of challenges with his symbiotic powers.
Green Goblin is very memorable. His crazy laugh and the flying glider make him stand out. He has a complex relationship with Spider Man as Norman Osborn is also connected to Peter's personal life.
Another potential villain could be an ancient Wakandan enemy that was once thought to be defeated. But with Spider - Man now in the role of king, they see it as an opportunity to strike. This enemy might have some dark magic or long - forgotten technology that they use against Wakanda. Spider - Man would have to quickly learn about this enemy's history and weaknesses in order to protect his new kingdom.
There could be a new villain who is a master of illusions on a whole new level. This villain could create entire cities within illusions, trapping Spider - Man and making him question what is real and what is not. Another potential new villain could be a symbiotic - like being that attaches itself to other people and turns them into powerful minions. Spider - Man would have to not only fight these minions but also find a way to destroy the main symbiotic - like villain at the source.
Doc Ock is a likely villain in Spider - Man angry fanfiction. His mechanical arms and his intelligence make him a formidable foe. His evil plans usually put the city in danger, and Spider - Man would be extremely angry trying to stop him. Also, Electro could be a villain in such fanfictions. His ability to control electricity can cause a lot of destruction, and Spider - Man would be angry at his disregard for human life while causing chaos.