Adam Warlock kills Thanos in comics through a combination of his cosmic powers, intelligence, and teamwork with other heroes. The specific circumstances vary depending on the comic series and plotline.
Well, in this graphic novel, Deadpool's wacky and unpredictable nature clashes with Thanos' power - hungry and often brooding demeanor. It makes for some really interesting and comical battles.
A possible plotline is that Thanos hears about the powerful chakra in the Naruto world and decides to conquer it. Naruto stands up to him, and during the fight, Naruto unlocks a new form of his power that is on par with Thanos' strength with the Infinity Stones. Along the way, Naruto teams up with some of his old foes who also realize the danger Thanos poses. They all fight together to protect their world.
The plot typically involves the Avengers facing off against Thanos. Thanos usually has some grand plan, like gathering the Infinity Stones to reshape the universe. The Avengers must come together, using their unique powers and teamwork, to stop him from achieving his malevolent goals.
One possible storyline could be that Thanos arrives on Earth seeking a powerful artifact. Superman steps in to stop him. They battle it out across the city, with Superman using his strength and speed to try and take down Thanos. Another could be that Thanos somehow manages to get Superman under his control using the Infinity Stones, and then the rest of the Justice League has to figure out how to free Superman and defeat Thanos.