One interesting plotline could be Deku having to face off against his classmates in a series of challenges that test not only their quirks but also their teamwork and strategic thinking. Maybe there's a misunderstanding that leads to the conflict.
Midoriya would initially be in shock. But then, his heroic instincts would kick in. He might try to analyze Toga's behavior and find a way to use it against her. For instance, if he notices that she gets distracted easily, he could create a diversion. He would also be thinking about the safety of others. He might worry that Toga has some bigger plan that involves harming his classmates or the city. So he would be constantly looking for a way to not only escape but also stop Toga's potential evil plans. And throughout all this, he would be drawing on his training at U.A. to keep his composure and think rationally.
Deku himself is likely to shine. Given his powerful quirk and his growth throughout the main series, he'll surely put up a great fight against his classmates. Bakugo could also shine as he's always been in competition with Deku and has a very strong quirk.
Definitely not. Midoriya's character is very much alive in the manga. The creators have no intention of killing him off as he's a key figure in driving the narrative forward and inspiring other characters.
His closest friends like Ochaco Uraraka and Tenya Iida would most likely side with him. They have always been there for Midoriya and share his values of justice and doing what's right. Also, those heroes who have seen Midoriya's growth and believe in his pure intentions would probably join his side.
Midoriya's character development would be quite distinct. In his new form as a girl, he would have to re - evaluate his self - identity. He's always been a determined boy with a strong sense of justice. But as a girl, he might find that the world expects different things from him. This could lead to a struggle between his old self and the new self he's becoming. He might also develop a more nurturing side, which could enhance his hero capabilities in a different way. For instance, he could be better at calming down panicked civilians during a disaster. He would also have to deal with new forms of discrimination or assumptions based on his new gender.
Some popular Midoriya fanfics often explore his growth as a hero. For example, 'Midoriya's Hidden Power' which delves into him discovering a new quirk. Another is 'Midoriya and the Mentor', where he gets special training from an unexpected source. And 'Midoriya's Team - New Beginnings' focuses on his leadership within a new team formation.
In a midoriya x uraraka fanfic, the author might play with the idea of their unspoken feelings. Uraraka's admiration for Midoriya could be delved into deeper, and Midoriya's possible realization of her importance in his life. It could also include some cute moments like when they train together or share a meal, which would add a lot of charm to the story.