In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
Wu Zhu had displayed even greater strength in his fight with Ku He. In the two exchanges, Ku He had been easily defeated by Wu Zhu, even admitting defeat in one move. In addition, Wu Zhu was able to easily defeat Lin Gong and the other experts, demonstrating his unfathomable martial arts and powerful combat abilities. Thus, according to the information provided, it could be assumed that Wu Zhu had the advantage in his battle with Ku He and had the ability to defeat him.