The characters in DxD would be quite shocked at first. Ichigo's appearance and his powers are so different from what they are used to. For example, Rias Gremory would probably be intrigued by Ichigo. She might try to form an alliance with him, seeing his potential as a powerful ally. Issei, being the main character in DxD, would likely be both jealous and in awe of Ichigo's abilities, and might challenge him at first but then learn from him over time.
Issei would probably be the first to want to fight Thanos. He's always eager to prove himself and protect his friends. He might initially underestimate Thanos due to his own growing power and confidence, but soon realize how powerful Thanos really is. Rias would be more cautious. She would likely try to gather information about Thanos first and then formulate a plan to either fight or negotiate with him.
Issei, being the hot - blooded character he is, would probably be excited to meet someone as powerful as Naruto. He might challenge Naruto to a friendly spar at first, hoping to learn from him and test his own strength. And as he gets to know Naruto better, he could start to see him as a brother - in - arms, especially if they face common enemies together.
Rias would be devastated. Issei was not only her servant but also someone she had deep feelings for. She would likely go into a rage at first, vowing to find and punish whoever was responsible. Akeno would be heartbroken as well. She and Issei had a special bond, and she would be in mourning for a long time. Kiba might feel a sense of guilt, wondering if he could have done more to protect Issei. Asia would be in shock and constantly pray for Issei's soul, hoping for some kind of miracle.
Issei would probably be both scared and excited. He's used to dealing with powerful beings, but the Ghost Rider is on a whole different level. He might initially try to fight him out of bravado, but soon realize he's outmatched. Rias would be more cautious. She would see the Ghost Rider as a potential threat to her peerage and would try to figure out his motives before taking any action.
Naruto characters' reactions would vary. Shikamaru would likely find the whole situation troublesome. He doesn't like getting involved in things that are too complicated. But Naruto would approach the archangel with his usual enthusiasm. He'd want to be friends and learn about the archangel's world. Hinata would be shy but also intrigued. She might see the archangel as a very noble and powerful being. And Kiba with Akamaru would be a bit more aggressive in their approach, ready to defend themselves if needed but also eager to know more about this new entity.
He might react with hostility. Dark Naruto has a certain edge to him, and if he sees Rias as a threat or someone he doesn't like, he'll likely oppose her. He could use his combat skills to challenge her directly.
Some characters might be intrigued. For instance, Issei might be curious about Fem Naruto's fixation on Ophis. He could see her as an interesting addition to their world and might try to understand her motives. Rias, on the other hand, might be more cautious. She would likely be concerned about how Fem Naruto's admiration for Ophis could affect the balance of power in their territory.
Naruto's reaction could be a mix of sadness and resolve. He has a big heart, so the betrayal would cut deep. But he also has the will of fire within him. He could use this as fuel to rise above the situation. He might seek out new allies in the High School DxD world, like Issei and his friends (if they weren't part of the betrayal). Together, they could work towards uncovering the truth behind the betrayal and taking on any threats that might be related to it.
The other characters in the Highschool DxD world would have a wide range of reactions. The angels might see Optimus as an unknown factor and be a bit suspicious. The fallen angels might try to manipulate the situation to their advantage. And the normal human students would be terrified at first. But as the story unfolds and they see Optimus Prime's noble actions, they could start to look up to him as a hero, much like how the Autobots are seen as heroes in their own universe.