Makima's fate in the manga is quite complex and involves a series of dramatic events. She faces powerful opponents and has her own agenda that leads to significant developments.
The obvious main characters would be the animator and the animation itself. The animator could be a young, creative person who is just starting out and is still learning how to control their creations. The animation could be a simple character that was initially designed to be a friendly helper but then turns against the animator.
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Well, Makima's death in the manga is the result of a series of events and confrontations. It's not straightforward and is tied to various character interactions and plot twists.
One idea could be that the animation gains self - awareness and tries to create its own world within the digital realm, away from the animator's control. This would lead to a conflict as the animator wants to bring it back to the original plan.