In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
One possible fanfic could be about Goku's intense training before the Cell Games. He might be shown pushing his limits in the Hyperbolic Time Chamber, trying out new techniques and forms to defeat Cell. Maybe he discovers a new power level that no one, including himself, expected.
It could be someone from Goku's past who has a vendetta against him and takes advantage of the chaos during the Cell Games. For instance, an old enemy who was thought to be defeated but managed to come back stronger and wants to finish Goku off while he's weakened from the fight with Cell.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.