The Highschool DxD manga has indeed finished. It wrapped up after completing all the planned story arcs and providing a satisfying conclusion for the readers.
If Spawn were to interact with the main characters, he would bring a whole new level of seriousness. He has a dark past and a lot of baggage. When it comes to Issei's goal of becoming a harem king, Spawn might find it absurd but also interesting in a way. He could offer his own perspective on power and how to use it responsibly, which would be a contrast to the more carefree attitude of some of the Highschool DxD characters. And with the other characters like Akeno and Koneko, he'd be sizing them up, trying to figure out if they're threats or allies.
The storylines can be combined by creating a common threat. Suppose an enemy emerges that is interested in both the power of the Bijuu and the power sources in Highschool DxD. This would force the characters from both universes to team up. Also, the cultural differences between the Naruto world and the Highschool DxD world can be explored. Naruto could introduce concepts like ninja clans and shinobi training to the DxD characters, while they could introduce him to the complex social hierarchies and supernatural politics in their world.
These fanfictions expand the Highschool DxD universe by introducing new characters like male Nekoshou. For example, they can create new storylines around their powers and how they interact with the existing characters in the DxD world. It might be a male Nekoshou with a special ability that changes the power dynamics in the school.
Naruto would probably be very friendly and curious. He'd be excited to meet all the different types of beings in the Highschool DxD world. He might start by trying to make friends with Issei, sharing his stories about his own battles and adventures in his world.