In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
The person Wu Zhu could not defeat was the Qing Emperor. In " Celebrating Years," Wu Zhu and the Qing Emperor had an intense battle. In the end, because Wu Zhu had exhausted a large amount of physical strength, he lost to the Qing Emperor. Although the Qing Emperor was also injured, he still stood on the field and could be considered the victor. Therefore, Wu Zhu could not defeat the Qing Emperor in his battle with him.