I'm not entirely sure specifically what 'primera mujer premio novel' refers to without more context. It could potentially be about the first woman to win a novel - related prize.
Nezuko is initially 12 years old in the manga. As the story unfolds, her age doesn't change significantly in a traditional sense, but her character development is quite remarkable.
A simple Nezuko and Zenitsu fanfiction could be that they go on a journey together. Along the way, they encounter other demon slayers who are initially skeptical of Nezuko. But Zenitsu stands up for her, explaining that she's different. This shows the depth of their friendship and how Zenitsu has come to trust Nezuko completely.