Sasuke often appears in different story arcs of the Boruto manga, depending on the current plot and mission. Sometimes he's on a solo mission, sometimes he's involved in events related to the village.
The team dynamic would be completely shattered. Sakura would be devastated as Sasuke was someone she had strong feelings for. Kakashi too would feel responsible for not being able to protect Sasuke. This could lead to the team splitting up or at least going through a long period of internal turmoil and lack of cooperation. And it might also change the way the village views their team, perhaps with disappointment or a sense of loss.