In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
One Punch Superman Saitama VS Tornado was the 191st chapter.
Chapter 191," Tornado's Counterattack ", tells the story of the battle between Saitama and Tornado. The two met on the street and Saitama was provoked by Tornado and was involved in the battle. In the battle, Tornado displayed her powerful strength. She used a type of Qigong wave called "Tornado" to attack her opponent, forcing Saitama to display even more strength to fight against her. In the end, Saitama defeated Tornado through his relentless efforts, demonstrating his unparalleled strength and tenacious will.
Another theme could be the clash of different universes. Amazo is from the DC universe and Saitama is from One Punch Man. Fanfics might play around with how these two different universes' rules and powers interact when these two characters meet. Also, there could be themes related to respect and rivalry. Saitama is often very nonchalant about his power, while Amazo is a complex android with various abilities. How they view each other in the fanfic can create interesting storylines.
Saitama would win. He has shown incredible strength with just one punch. His power seems limitless, and in a fanfiction scenario, his simplicity and raw power would likely overpower Jiren's more complex abilities.
One possible plot twist could be that Jiren discovers a way to nullify Saitama's strength. Maybe he finds some sort of energy - draining technique that weakens Saitama over time. Another could be that Saitama holds back for some reason, like he wants to see the full extent of Jiren's power, and in doing so, he gets into a real struggle.
In a Saitama vs OC fanfiction, a plot twist could be that the OC has the power to make Saitama lose his strength. However, the OC doesn't want to use this power because they admire Saitama and want to test their own strength against him fairly. Another interesting twist could be that the OC is a part of a bigger plan by some mysterious organization. They use the fight against Saitama as a distraction while they carry out their real objective elsewhere. And as the fight progresses, Saitama realizes this and has to decide whether to continue the fight or go after the real threat.
Well, it really depends on how the OC (Original Character) is designed. If the OC has some really unique and powerful abilities that can counter Saitama's strength, like the ability to nullify physical attacks or something really out - of - the - box, then the OC might stand a chance. But Saitama is known for his one - punch knockout power. So, in most cases, Saitama would probably win due to his overwhelming strength that has defeated almost every foe he's faced so far.
A lot of fanfictions play with the idea of Boros having some hidden power or strategy that makes the fight more intense and less one - sided than in the original. For example, he might have a power - up that actually challenges Saitama for a while. Another plot could be a time - travel twist where someone goes back in time to change the outcome of the Saitama vs Boros fight, which then has all kinds of consequences for the One Punch Man universe.