The Lonesome Road in New Vegas is a desolate and dangerous place. It's about a courier's journey through this harsh area filled with challenges. There are various factions and threats along the way.
The story of Fallout: New Vegas centers around the struggle for power and resources in the Mojave Wasteland. You play a courier who gets caught up in a web of political intrigue and must navigate through different factions with their own agendas. There's a lot of exploration, combat, and decision-making that affects the outcome.
The position of New Vegas in the main story is significant. It presents various challenges and plot developments that contribute to the overall richness of the story. It's neither at the beginning nor near the end but holds a crucial middle ground.
The Sierra Madre story in New Vegas is a tale of mystery and adventure. The Courier finds themselves in this strange place. It was once a grand casino/resort but now is a desolate and dangerous area. The story has a lot to do with the idea of greed and survival. There are valuable things in the Sierra Madre but getting to them means facing off against the Ghost People, surviving the Cloud, and solving the many puzzles and traps that are scattered throughout the area. It's a story that tests the Courier's skills and will to survive.