Well, their friendship could potentially change Sasuke's path. Since Sakura is friends with Itachi, she might be able to communicate better with Sasuke about his brother. For example, she could tell Sasuke about the good side of Itachi that he never knew, which could make Sasuke less vengeful and more focused on rebuilding his clan. This would be a huge shift from the original storyline where Sasuke is mainly driven by revenge against Itachi.
A possible plotline could be that they made a childhood promise to always protect each other's families. When Itachi is faced with the decision to kill his clan, Sakura tries to stop him, not fully understanding the situation at first. This creates a rift between them, but later, as Sakura learns the truth, she tries to help Itachi in her own way, like protecting Sasuke from the shadows as Itachi had asked her to in a moment of desperation.
One possible plot could be Itachi and Sakura bonding over their love for medicine. Sakura is a talented medical ninja, and Itachi has knowledge of various herbs and healing techniques from his clan. They could start sharing their knowledge, and Sakura could learn some unique Uchiha healing methods from Itachi. This would not only strengthen their friendship but also help Sakura become an even better medic. As their friendship grows, they might face challenges together, like having to deal with rogue ninjas who are after Itachi's Sharingan or Sakura's medical knowledge.
One way is to show them sharing simple pleasures like climbing trees together. Sasuke could be the brave one helping Sakura reach the highest branches. This would symbolize his role as her protector in childhood.
Their relationship could have a positive impact on Sasuke. Itachi could use his friendship with Sakura to try and get closer to Sasuke again. Sakura, being Sasuke's teammate, could act as a bridge between the two brothers. She could encourage Sasuke to open up to Itachi, and Itachi could use this opportunity to try and make amends for his past actions. This could lead to a more positive family dynamic for Sasuke.
Probably not. Drugging is a very serious and unethical topic, and in a fanfic context, it might be disturbing and inappropriate, especially for younger audiences who are fans of the Naruto series.
There could be. The Naruto universe has a huge fan base, and fanfics often play with unexpected character relationships. Sakura, being a character with her own set of interests and curiosities, might be depicted as an Itachi fan in some fan - made stories. Maybe she admires his powerful jutsu or his self - sacrifice in certain fics.
Yes, there are likely some fanfics out there with such a plot. Fanfic writers often come up with unique and unexpected pairings or storylines. However, the popularity of this specific concept might vary. You can try searching on popular fanfic websites like FanFiction.net or Archive of Our Own to find if there are any stories where Itachi shows interest in Sakura.
Kakashi, as their sensei, would be disappointed. He would hope that they could resolve their differences maturely. He might offer some advice based on his own experiences in relationships, but ultimately it would be up to Itachi and Sakura to decide whether to take it or not.