In this kind of fanfiction, Itachi might use his powerful Sharingan abilities. He could perhaps create illusions to mislead Orochimaru and his minions, then quickly snatch Sasuke away. For example, he could make Orochimaru think that Sasuke is in a completely different location while he secretly approaches and rescues him.
It shows the strong bond between the two brothers. Despite all the complications in their relationship, Itachi still cares deeply for Sasuke and is willing to risk a lot to save him from a great danger like Orochimaru.
In fanfiction, Sasuke might save Sakura from Orochimaru by using his Sharingan. His powerful eyes could detect Orochimaru's moves and counter them, allowing him to rescue Sakura.
In the fanfiction, Itachi might be acting according to some secret mission that endangers Sakura's life. Sasuke, who has a strong bond with Sakura now, won't let that happen. He jumps in and uses his ninja skills. Sasuke could have developed some new jutsu that he uses to counter Itachi's attacks. This not only saves Sakura but also shows Sasuke's growth as a ninja. And Sakura, in turn, might be in the middle of researching some important medical ninja stuff that Itachi's actions could have disrupted if not for Sasuke.
One possible scenario could be Naruto arriving just in time as Orochimaru is about to perform a dangerous jutsu on Sasuke. Naruto uses his new Rasengan variant, overpowering Orochimaru and rescuing Sasuke. It would be a very action - packed moment.
Sasuke's character could develop in terms of his loyalty. By saving Sakura from Itachi, he shows his loyalty to his friends and comrades. He is no longer just the revenge - driven Sasuke. He has grown to care about others' safety.
Naruto's character might develop a stronger sense of purpose. Saving Sasuke becomes more than just about their friendship; it could be about righting a wrong in the ninja world. His resolve to save Sasuke would make him train harder and become more strategic in his battles.
Perhaps in this fanfiction, Naruto has some sort of special power or transformation that he unlocks just in time to face Orochimaru. It could be related to his Nine - Tails chakra in a new and unique way. He uses this power to break through Orochimaru's defenses and save Hiruzen. Naruto might also use his knowledge of Orochimaru's weaknesses that he has learned either from Jiraiya or from his own past encounters with Orochimaru's minions.
Sasuke could save Sakura from Orochimaru by outsmarting him. Since Sasuke is very intelligent, he might come up with a clever plan to get Sakura away from Orochimaru's clutches.
In this kind of fanfiction, perhaps Itachi uses his quick reflexes and ninja skills to catch Sakura as she's about to fall. Maybe she was in a dangerous situation like on a crumbling cliff or a collapsing building. Itachi, being the powerful ninja he is, swoops in just in time to prevent her from getting hurt.