It could be due to a family secret. Suppose his family was involved in something dangerous or unethical that Naruto couldn't bear. For example, if they had ties to an enemy organization that Naruto discovered. He is a character with a strong sense of justice, so running away would be a way to distance himself from their actions and figure out how to deal with the situation on his own.
They would probably start searching for him. This could lead to the family members getting closer as they united in their goal to find Naruto. Or it could cause conflicts among them if they blamed each other for Naruto's running away.
Some of his friends might feel betrayed. They could think that Naruto didn't trust them enough to share his problems about his family. For example, Sasuke, who has his own issues with family, might initially be angry at Naruto for running away instead of facing the family situation together like they face other challenges.
One possible reason could be that he felt misunderstood. In the Naruto series, Naruto was often an outcast in the village. Maybe in this fanfiction, his family didn't understand his dreams or his need for recognition. So he ran away to find a place where he could be himself.
It could be that Naruto discovers some secrets within his family that make him feel uncomfortable or out of place. For example, if there are hidden agendas or dark pasts that he doesn't want to be associated with, he might choose to move away to start anew.
One possible plot could be that Naruto feels constantly overshadowed by his family's expectations. Maybe his family is full of powerful shinobi and they expect him to be just as great immediately. He runs away to find his own path and prove himself on his own terms. Along the way, he meets new friends who are also outcasts and together they form a sort of 'family' that accepts him for who he is.
The family would be shocked at first. They might start to question their actions towards Naruto. If they were too strict or didn't give him enough love, they would feel guilty. For example, his father may realize that he pushed Naruto too hard to follow a certain path and now regrets it.
It would create a sense of panic. Naruto is a very important figure in Konoha. His strength has been crucial in protecting the village. Without him, the villagers would fear attacks from other villages or threats from the Akatsuki. For instance, if the Akatsuki knew Naruto had left Konoha, they would likely see it as an opportunity to capture him more easily.
It might be that his family is overprotective. Naruto is a very independent character. If his family in the fanfiction is constantly trying to hold him back from taking risks or going on adventures, he may feel suffocated. Running away would be his way of breaking free and exploring the world on his own terms.
One possible reason could be that he felt misunderstood. In the village, Naruto was often ostracized despite his good intentions. Maybe he got tired of trying to prove himself and just ran away. For example, when the villagers still saw him as the nine - tailed fox rather than Naruto, it might have pushed him to leave.