As mentioned before, 'Flowers for Algernon' is quite well - known. It tells the story of Charlie, a man with a low IQ, and Algernon, the mouse. The experiments on Algernon are a central part of the story, and it shows how the mouse's experience is linked to Charlie's own journey, which is a great example of a book that combines animal experimentation and mouse - related fiction.
I'm not sure if there are a great many books that specifically combine these two topics directly. However, 'The Island of Doctor Moreau' by H.G. Wells could be relevant. It's about a mad scientist's experiments on animals, and while not centered on mice, it shows the horror and ethical dilemmas of animal experimentation. And there might be some elements that can be related to the idea of mouse fiction in the sense of the fictional exploration of animals in an experimental context.
One major ethical concern is the pain and suffering inflicted on animals. Many animals are subjected to invasive procedures, such as surgeries without proper anesthesia in some unethical cases. They may be caged in small spaces for long periods during experiments, which is cruel.
One example is the development of insulin. Before its discovery, diabetes was a fatal disease. Scientists used dogs in their experiments. They removed the pancreas of dogs to study diabetes symptoms, which led to the discovery of insulin and its role in regulating blood sugar. This has since saved countless human lives.
One interesting story is about Pavlov's dog experiments. Pavlov studied the salivary response in dogs. He noticed that dogs would salivate not only when presented with food but also when they heard certain sounds that were associated with food. This led to the discovery of classical conditioning. It was a significant finding as it showed how animals can be conditioned to respond in a certain way based on associated stimuli.
In some laboratories, monkeys are used for brain - related experiments. Electrodes are inserted into their brains without proper anesthesia in some unethical setups. These monkeys are then forced to perform tasks while their brain activities are monitored in a very invasive way. This not only causes physical pain but also extreme psychological distress for the poor animals.
One great example is 'The Island of Dr. Moreau' by H.G. Wells. It tells the story of a scientist who conducts cruel experiments on animals, turning them into human - like creatures. Another is 'Flowers for Algernon' which involves an experiment on a man with an intellectual disability to increase his intelligence. And 'Brave New World' by Aldous Huxley also features elements of human experimentation in its dystopian society where people are genetically engineered and conditioned.
Animal experimentation stories have provided a wealth of knowledge. For example, the discovery of penicillin was partly due to animal experiments. Scientists tested the antibiotic on mice first to see its effectiveness against infections. This showed that it could be used to treat bacterial infections safely in animals, which led to its use in humans. So, these stories have directly influenced the development of life - saving drugs.
One popular one is 'The One and Only Ivan'. It has been well - received for its poignant portrayal of the life of an animal in a human - made environment.
Human experimentation fiction books explore ethical issues in various ways. Take 'Never Let Me Go' for instance. The clones in the story are created and used for organ donation without their real consent. It makes us question the morality of using human life as a resource. These books often put the reader in a position to consider whether the ends of scientific progress justify the means of experimenting on humans, and how we should define the boundaries of what is acceptable in the name of science and progress.