He might be initially shocked. Naruto is used to thinking of Hana as an ally, so if she hurts him, it would be unexpected. He could immediately try to get some distance to assess the situation and figure out why she did it.
A plotline could be that Hana is jealous of Naruto's popularity or power. So, she decides to challenge him and in the heat of the battle, she ends up hurting him. Naruto, on the other hand, is shocked by her actions and tries to talk to her to find out why she did it. This could then turn into a story about friendship and forgiveness, as Naruto may choose to forgive Hana and help her overcome her jealousy issues.
It's also possible that Hana is related to one of Naruto's friends. Maybe she's Kiba's sister or something. And because of her connection to Naruto's friend, Naruto feels responsible for her safety. So when she's in trouble, Naruto steps in to save her without hesitation.
Hana could be an original character created for this fanfiction. Maybe she is a new ninja in the village who Naruto falls for, but she has a hidden agenda that ends up breaking his heart.
In a fanfiction, Naruto could befriend Hana and Tsume in a different context than in the original series. For example, they might meet during a training session in a hidden forest. Their different personalities would create interesting dynamics. Naruto's optimism, Hana's calmness, and Tsume's intensity would all play a role in how they interact.
One possible fanfiction could be about Naruto, Hana, and Tsume teaming up on a mission. Maybe they have to protect a hidden village from a new threat. Naruto's strength, Hana's skills with animals, and Tsume's fierce combat abilities could make for an exciting story.
One possible fanfiction could be about Naruto going on a mission with Tsume and Hana. They might encounter a powerful enemy in the forest. Naruto could use his shadow clone jutsu to distract the foe while Tsume and Hana attack from the sides. This would showcase their teamwork and different fighting styles.
Naruto, Tsume, and Hana could be involved in a story where they have to solve a mystery in the village. It could be related to some strange disappearances. Naruto's intuition, Tsume's experience, and Hana's intelligence would all come into play as they try to figure out what's going on.
Another fanfiction could revolve around a festival in the Hidden Leaf Village. Naruto, Hinata, and Hana participate in different festival activities. Hinata might be shy at first but with Naruto's encouragement and Hana's friendly nature, they all have a great time. It could also include some romantic moments between Naruto and Hinata in this festive setting.