You need to start with simple sketches and get familiar with the characters' features. Then, focus on the humor and style that makes Cyanide and Happiness unique.
You need a good sense of humor and the ability to draw simple yet expressive characters. Start by coming up with funny and quirky ideas for the comic strips.
Cyanide & Happiness comic strips typically feature simple but funny characters and situations. They don't hold back on being edgy and can be quite irreverent.
To make comics like Cyanide and Happiness, focus on simple yet impactful art. Their illustrations are usually straightforward but convey the message clearly. Also, be brave in exploring unconventional and sometimes controversial themes.
They come up with crazy and funny ideas first, then draw them in a unique style. The process involves a lot of creativity and collaboration among the team.
I'm not entirely sure specifically what that particular 'cyanide and happiness reaction fanfic' is about without reading it. It could be a fan - created story based on the 'Cyanide & Happiness' series that focuses on the reactions of the characters in different scenarios, perhaps some really wacky or dark humor - filled situations that are typical of the original content.