The key event was the apparition of the Virgin Mary to him on Tepeyac Hill. Another important event was his interaction with the bishop to convey Mary's message about building a church.
San Juan Diego was an indigenous Mexican. He is best known for his encounter with the Virgin Mary. According to the story, Mary appeared to him on Tepeyac Hill. He was a simple and devout man. His experiences led to the building of the Basilica of Our Lady of Guadalupe, which has become a very important religious site in Mexico and is visited by many pilgrims every year.
Well, it could be about various things like local events, new businesses opening in San Diego, or some community achievements. Maybe there are stories about famous local personalities too.
At present, there are no official plans for Comic Con to leave San Diego. The location has become iconic for the event and there's a lot of infrastructure and fan support in place.