The Whisperers are defeated through a combination of strategic planning and teamwork among the main characters. They manage to outsmart the Whisperers' tactics and expose their weaknesses.
The Whisperers' fate in the comics is sealed through a combination of factors. They underestimate their opponents' determination, and their tactics fail. This leads to their gradual downfall and ultimate deaths in different intense battles.
The Whisperers storyline in The Walking Dead comics was quite intense. They emerged as a major threat, using disguises made of walker skin to blend in and cause chaos.