Sort of. The core idea and themes of the story have roots in real experiences, but the specific plot and characters have likely been fictionalized and embellished to create a more engaging narrative.
Well, 'My Sister's Keeper' is a really touching story. It shows how a family is centered around the sick sister Kate. Anna, the younger sister, has been donating things like blood, bone marrow etc. for Kate all her life. But as she grows older, she realizes she has her own life to live. The court case she files against her parents is a major part of the story. It makes everyone think about what is right and wrong in such a difficult situation where a family is torn between saving one child and respecting the rights of another.