I don't think so. Comic Thanos has access to cosmic powers and strategies that could pose a serious challenge for Goku. His intelligence and the extent of his powers might be too much for Goku to overcome.
I think it depends on various factors. Goku's determination and growth are remarkable, but Beerus has an overwhelming level of power and authority that might be difficult to overcome.
Saitama from One Punch Man could be a contender. His ability to defeat any opponent with a single punch might just work against Goku. However, Goku's diverse skills and transformations would make it an epic battle.
Shinra stands no chance against Goku. Goku has gone through countless battles and has mastered powerful techniques. His strength and experience give him a huge advantage.
Well, characters like Thor, with his godly powers and Mjolnir, or Thanos with his immense strength and intelligence, might have a chance against Wanda in the comics. It often depends on the specific circumstances and plotlines.
Another way is that Goku could use the Spirit Bomb. He could gather energy from all living things on Earth and nearby planets. Android 21, being an artificial being, might not be able to withstand the pure energy of the Spirit Bomb. However, she could try to absorb the energy, but if Goku can overload her absorption capabilities, it would be his victory.
In general, it's a bit of a toss-up. The strength of Manga Goku and Anime Goku can vary depending on the specific arcs and battles. Sometimes, it might seem like one is stronger in a particular situation, but that could change in another.
In the light novel, there are a few powerful characters who might have a chance to defeat Rimuru, but it depends on various factors like the circumstances and their own powers.
Well, Vegeta would be a likely character. He might be initially suspicious of the female Goku. Maybe he thinks she's a threat or just can't believe there's another Goku - like being. He could be there to add some comical moments as he tries to understand the situation.