The Spiderman comics were primarily made by Stan Lee and Steve Ditko. Their collaboration brought this iconic character to life. Stan Lee provided the story ideas and character concepts, while Steve Ditko did the art and helped shape the visual look of Spiderman.
The best Spiderman in comics is subjective. Some love Ben Reilly for his complex character arc and determination. It really comes down to what aspects of the character you value the most.
It could be Doctor Octopus. He might have some new, more dangerous tentacle - like devices. He decides to target both Spiderman and female Spiderman because he views them as obstacles to his scientific experiments and his desire for power. He kidnaps some innocent people to lure them into his traps and tries to defeat them in a fight.
It's not so straightforward though. Daredevil is a highly skilled martial artist and his enhanced senses could potentially allow him to anticipate Spiderman's moves. If the fight took place in a very enclosed and dark space, Daredevil might be able to use the environment to his advantage and land some good blows on Spiderman.
Doctor Strange often appears in Spiderman dimension travel fanfiction. Since he is an expert in the mystic arts and has knowledge about different dimensions, he can be a guide or an accidental cause of Spiderman's dimension travel. Another common character is Venom. In different dimensions, Venom can have different forms and motives, which makes for an interesting story when combined with Spiderman's dimension - hopping adventures.
In some creative fanfiction, it could be an alternate version of Spiderman himself from a different dimension. This Spiderman has gone bad and kidnaps a fan from our dimension as part of some grand, dark plan that involves crossing dimensions and causing chaos.