There may be. In the world of fanfiction, creativity knows no bounds. Writers may choose to write a story where Harry is not Hermione's friend for various reasons. It could be to introduce a new conflict, or to show how the other relationships in the story would be affected. However, it would be a departure from the warm friendship they share in the books, and might not be well - received by all fans.
Maybe Harry and Hermione have a misunderstanding at the very beginning, like a fight over a Quidditch match result that gets out of hand. So they decide to not be friends. Then, Hermione might form an alliance with Draco out of spite towards Harry, and Harry could find himself more alone and start to rely more on Neville. This could lead to a whole new set of adventures and challenges in Hogwarts.
Luna Lovegood might be a candidate. Luna has a unique perspective, and Hermione might be drawn to her quirkiness early on. They could meet in the library, both reaching for the same rare magical book, and start chatting about their different views on magic, thus beginning their friendship.
It could be a shy Hufflepuff student who has been observing Harry for a long time. This student might have some special powers or knowledge that they keep hidden. They become Harry's secret friend because they are afraid of being bullied or judged if their abilities are known.
One possible reason could be if Harry takes a big risk without consulting her first. In the wizarding world, their adventures are full of danger, and Hermione is often the cautious one. If Harry jumps into a situation like facing a powerful dark wizard alone without a proper plan, Hermione would likely blame him for being reckless.
The White Walkers could be major antagonists. They are a huge threat in Westeros and Harry and Hermione would have to use their unique magical abilities to combat them. Their cold - based magic and army of the undead would be a great challenge for Harry and Hermione.
The neighbor situation could make their relationship more open. They would have more opportunities to see each other without the hustle and bustle of Hogwarts. This could lead to them sharing more personal stories. For instance, Harry could tell Hermione more about his early years with the Dursleys, and Hermione could share her experiences growing up as a Muggle - born witch. This sharing of personal histories would likely strengthen their bond.
Another motive might be related to a dark object influencing her. If Hermione came across a cursed object, like a dark locket that amplified negative emotions such as envy or fear, it could drive her to kill Harry. Maybe she started to envy Harry's fame and the special attention he always got, and the locket pushed her over the edge.
One specific moment could be when Hermione is stressed about a big project for school. Harry might bring her a cup of tea and sit with her while she works, just being a calming presence. He could say things like 'Hermione, you're the smartest witch I know, you'll do great on this' to boost her confidence.
In many fanfictions, Harry might comfort Hermione by simply being there for her. He could sit quietly beside her while she's upset, offering his silent support. Maybe he'll hold her hand gently to let her know she's not alone.