In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
Wu Zhu was considered one of the grandmasters at the peak of martial arts and possessed powerful sword techniques. The Shadow was Chen Pingping's personal guard. Although he had been taught by Wu Zhu, his strength was not as good as Wu Zhu's. Thus, according to the information provided, the shadow was unable to defeat Wu Zhu. In addition, the Qing Emperor was described in " Celebrating Years " as the pinnacle of human combat power. He possessed top-notch mental strategies and martial arts. The Qing Emperor practiced Tyrannical zhenqi, which contained a lot of zhenqi. However, other than zhenqi, the Qing Emperor was not much different from ordinary people. Although there was no clear mention of whether the Qing Emperor could defeat Wu Zhu, according to the information provided, Wu Zhu's strength was considered invincible, so it could be inferred that Wu Zhu could not be defeated.