I'm not sure specifically as I haven't read this exact novel. But generally, it might be about a situation where a villain makes a wrong move by coming to the wrong house, and perhaps there are various consequences, battles, or revelations that follow from this mistake.
The main characters would probably include the villain. He is the one who sets the story in motion by coming to the wrong place. Then there could be the people living in the house. They might be ordinary people who are suddenly thrust into a dangerous situation, or they could be some sort of protectors or even hidden heroes. Maybe there's a wise old character in the house who has some knowledge or power that can be used against the villain, or a young and brave person who decides to take on the villain directly.
Most likely it isn't. Usually, such titles are works of imagination or inspired by various elements but not based on real events. The story could have been crafted to engage and captivate the audience rather than being a true account.
Well, when a villain meets a villain in manga, it can result in all sorts of scenarios. Sometimes they might try to outwit each other, and other times they could find common ground and work together, but with hidden agendas.
The problem with 'You Duke' manga might lie in its lack of originality or poor world-building. Also, the dialogue could be weak, making it hard for readers to engage.