Buffy's relationship with Spike in the comics varies. Sometimes they have significant interactions and may even be romantically involved, but it's not a constant throughout all the comic series.
It varies from comic to comic. Sometimes they have a romantic connection, while in others, their relationship is more complicated or not existent at all.
The status of Spike and Buffy's relationship in the comics varies. Sometimes they are shown as a couple, while in other instances, their relationship is more complicated or undefined. It all comes down to the particular comic series and its plot.
I don't have definite information. But sometimes characters come back in new comic series based on fan demand or to further the story. So there's a chance Spike could show up, but nothing's guaranteed.
One common theme is redemption. Spike's journey towards redemption and how Buffy fits into that is often explored. Another is the idea of forbidden love, as their relationship has always had elements of being something not quite accepted. Also, the theme of sacrifice comes up a lot, like one of them sacrificing for the other's well - being or for the greater good.