In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
In Madoka x Homura fanfiction, the power dynamics between them can be an interesting aspect. Madoka, as a very powerful magical girl, and Homura, with her time - looping abilities, have a unique relationship. Fanfiction could play with how they use their powers in relation to each other. Maybe in a fan - created scenario, they combine their powers to save a new threat that wasn't in the original series.