I don't know who the author of the 'last surviving alchemist novel' is. There are so many novels out there and this one may be relatively unknown or it could be a self - published work.
Well, without having read the 'last surviving alchemist novel', it could potentially revolve around the last alchemist's quest to preserve the secrets of alchemy. It could involve him facing opposition from those who want to destroy the art or his journey to find a successor to carry on the alchemical tradition.
Well, it might be about an alchemist who is the last of his kind. Maybe it involves his adventures, his search for something like the Philosopher's Stone, or his battles against other forces that are out to get him because of his alchemical knowledge.
The Last of Us was not a comic originally. It was first developed as a video game, which gained significant popularity and later inspired other related media, but the comic came later.
The main character is surely the last surviving alchemist. There may also be some side characters like his friends or foes. His friends could be those who support him in his journey, perhaps other scholars or people who believe in the power of alchemy. His foes might be those who want to use his knowledge for evil or those who oppose alchemy altogether.