Maybe the transformation into a girl makes Naruto discover a whole new side of the ninja world. Since she is now a girl, she is treated differently and has to adapt. However, she also finds that there are some advantages, like being able to get closer to certain female characters who were previously guarded around male Naruto. This new closeness helps in unravelling some secrets related to Orochimaru's motives for the transformation.
One possible plot twist could be that Orochimaru turns Naruto into a girl as part of a grand experiment. But Naruto, now a girl, still has his (or rather her) strong will and uses this new form to infiltrate an all - female group that Orochimaru wants to target. This way, Naruto can gather intelligence and thwart Orochimaru's plans from the inside.
A plot twist could be that Orochimaru's transformation into a girl is part of a larger, more complex jutsu that was set in motion long ago. In this new form, she has access to different types of chakra or abilities that she didn't have before. This makes her a target for other villains who want to use her new powers for their own gain, and Naruto has to protect her while also being cautious of her true intentions.
One possible plot twist could be that Kakashi, as a girl, has to deal with different social expectations in the ninja world. For example, she might face more restrictions in combat training because of her new gender. Another could be that she uses her new form to her advantage in undercover missions, fooling enemies who are less likely to suspect a female. Also, there could be a romantic plot twist where a character who previously saw Kakashi as a rival now has different feelings for her as a girl.
It could be that the bite was part of a larger plan by Orochimaru to create a new body for himself. Orochimaru is always seeking new vessels. He might think that Naruto, with his strong chakra and willpower, would be the perfect host. So, Naruto has to fight against Orochimaru's influence from within his own body, while also trying to figure out how to stop Orochimaru's overall plan.
One possible plot twist could be that Neji, as a girl, has to face different challenges in the ninja world. For example, she might initially struggle with the new physical limitations or advantages that come with being female in a male - dominated ninja society. Maybe she has to deal with different expectations from her clan and friends, which could lead to some interesting character development. Another plot twist could be in her relationships. Her former male friends might start to see her in a new light, leading to some complicated romantic or platonic dynamics.
Well, a possible plot twist could be related to Sasuke's family. Maybe when he turns into a girl, he discovers some long - hidden secrets about his family that were only accessible in this new form. Also, in the ninja world, being a female Sasuke could lead to different political implications. The other villages might view him/her differently and try to use this transformation to their advantage. It could also be a twist if Sasuke, as a girl, has to fight against gender stereotypes within the ninja community.
Well, a really interesting plot twist could be that the transformation into a little girl is part of a genjutsu cast by a powerful enemy. But while in this form, Naruto discovers new aspects of the ninja world that are usually hidden from male ninjas. Maybe there are secret female - only ninja techniques she stumbles upon and has to master to break the genjutsu.
One possible plot twist could be that Naruto's 'godlike' powers are not his own but are the result of some ancient curse placed on Orochimaru that backfires. For example, Orochimaru was trying to gain ultimate power and in the process, he unknowingly transferred a powerful and uncontrollable energy to Naruto. So when Naruto kills Orochimaru, it's like the curse has completed its cycle. Another aspect could be the emotional turmoil Naruto goes through. Even though he has to kill Orochimaru for the greater good, it still weighs on his conscience because Naruto is a character who values all life. He might struggle with the idea that he had to take a life, even if it was someone as evil as Orochimaru.
Well, perhaps in the fanfiction, Naruto kills Orochimaru and the Akatsuki, but it turns out that Orochimaru had a failsafe. His death triggers a powerful curse that starts to affect Naruto and the Hidden Leaf Village. Naruto then has to find a way to break this curse while also dealing with the remaining threats that were associated with the Akatsuki. It could be a race against time to save the village and himself.
Well, in a Good Orochimaru Adopts Naruto fanfiction, the plot could take an interesting turn when Orochimaru tries to train Naruto. Since Orochimaru has such different and often dark jutsu, Naruto might struggle to adapt. But this could lead to Naruto creating his own unique style of combat that combines his Uzumaki resilience with some of Orochimaru's knowledge. And then there's the matter of how the rest of the village reacts. They might be very suspicious of Orochimaru's intentions and try to take Naruto away, which would create a whole new set of conflicts.
One possible plot twist could be that Naruto is captured but instead of Orochimaru using him for his own power gain immediately, he tries to turn Naruto against Konoha. He might show Naruto some 'hidden truths' about the village that are actually lies or half - truths, creating internal conflict within Naruto. Another twist could be that Orochimaru's experiment on Naruto goes wrong in an unexpected way. Maybe Naruto's chakra reacts with Orochimaru's jutsu and creates a new form of power that neither of them can control at first.